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BAY1125976
Artikelnummer: TGM-T7315-100mg
Description: BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay). Target: Akt. Smiles: NC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1. References: Politz O , Siegel F , Bärfacker L, et al. BAY 1125976, a selective allosteric AKT1/2...
| Anwendung: | Allosteric Akt1/2 inhibitor |
| CAS | 1402608-02-9 |
| MW: | 383.45 D |
ab 33,00 €
BAY-1125976
Artikelnummer: Cay28913-1
BAY-1125976 is an allosteric inhibitor of Akt1 and -2 (IC50s = 5.2 and 18 nM, respectively, in a time-resolved FRET assay). It is selective for Akt1 and -2 over Akt3 (IC50 = 427 nM in the same assay) but does inhibit the activity of the receptor tyrosine kinases FLT1, -3, -4, and Mer by greater than 50% in a panel...
| Schlagworte: | 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-imidazo[1,2-b]pyridazine-6-carboxamide |
| Anwendung: | Allosteric Akt1/2 inhibitor |
| CAS | 1402608-02-9 |
| MW: | 383.5 D |
ab 43,00 €
