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MMG-0358
Artikelnummer: TGM-T71954-10mg
Description: MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme. Target: Others. Smiles: OC1=C(C=C(Cl)C=C1)C2=CN=NN2
| Anwendung: | IDO1 enzyme activity & inhibition experiments |
| CAS | 1378976-02-3 |
| MW: | 195.61 D |
ab 193,00 €
MMG-0358
Artikelnummer: AG-CR1-3630-M001
White solid. Soluble in DMSO or 5%DMSO/95%water mixture. Potent triazole IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor, Has IC50 values of 2nM in a cellular assay on mIDO1, 80nM in a cellular assay on hIDO1, 330nM in an enzymatic assay on hIDO1 at pH 6.5 and 71nM in an enzymatic assay on hIDO1 at pH 7.4. Shown to...
| Schlagworte: | 4-Chloro-2-(1H-1,2,3-triazol-5-yl)phenol |
| Anwendung: | Potent IDO1 inhibitor |
| CAS | 1378976-02-3 |
| MW: | 195,6 D |
ab 77,00 €
MMG-0358
Artikelnummer: Cay29828-5
MMG-0358 is an inhibitor of indolamine 2,3-dioxygenase 1 (IDO1, IC50s = 2 and 80 nM for the mouse and human enzyme, respectively). It is selective for IDO1 over tryptophan 2,3-dioxygenase (TDO, IC50s = >100 µM for mouse and human TDO).Formal Name: 4-chloro-2-(1H-1,2,3-triazol-5-yl)-phenol. CAS Number: 1378976-02-3....
| Schlagworte: | 4-chloro-2-(1H-1,2,3-triazol-5-yl)-phenol |
| Anwendung: | IDO1 inhibitor |
| CAS | 1378976-02-3 |
| MW: | 195.6 D |
ab 109,00 €
IDO1 (human) Enzyme+Inhibitor Set
Artikelnummer: AG-44B-0006-KI01
IDO1 is a heme-containing enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO1 is an immune checkpoint protein, that plays a role in a...
| Schlagworte: | IDO, IDO1, IDO-1, Indoleamine 2,3-dioxygenase 1, Indoleamine-pyrrole 2,3-dioxygenase, MMG-0358 |
| Anwendung: | IDO1 enzyme activity & inhibition experiments |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| CAS | 1378976-02-3 |
| MW: | ~47 kD |
506,00 €
