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GNE0877
Artikelnummer: TGM-T6031-100mg
Description: GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM). Target: LRRK2. Smiles: CNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1C(F)(F)F. References: Estrada AA, et al. J Med Chem. 2014, 57(3), 921-936.
| Schlagworte: | GNE-0877, GNE 0877 |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1374828-69-9 |
| MW: | 339.32 D |
ab 40,00 €
GNE-0877
Artikelnummer: Cay16251-1
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been...
| Schlagworte: | alpha,alpha,3-trimethyl-4-[[4-(methylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile |
| Anwendung: | LRRK2 inhibitor |
| CAS | 1374828-69-9 |
| MW: | 339.3 D |
ab 78,00 €
