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Ribociclib succinate
Artikelnummer: TGM-T15732-100mg
Description: Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and exhibits over 1,000-fold reduced potency against the cyclin B/CDK1 complex. Target: CDK. Smiles: OC(=O)CCC(O)=O.CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1....
| Schlagworte: | LEE011 succinate |
| Anwendung: | Antineoplastic, Cyclin-dependent kinase (CDK) inhibitor |
| CAS | 1374639-75-4 |
| MW: | 552.63 D |
ab 31,00 €
LEE011 (succinate)
Artikelnummer: Cay36414-10
LEE011 is a cyclin-dependent kinase 4 (Cdk4) and Cdk6 inhibitor (IC50s = 0.53 and 2.3 nM, respectively). It is selective for Cdk4/6 over Cdk1, Cdk2, Cdk5, Cdk7, and Cdk9 (IC50s = >1,400, >2,500, >2,000, >2,000, and 190 nM, respectively). LEE011 reduces the proliferation of MCF-7 and T47D breast cancer cells (IC50s =...
| Schlagworte: | NVP-LEE011, Ribociclib, butanedioic acid, compd. with... |
| Anwendung: | Cdk4/6 inhibitor |
| CAS | 1374639-75-4 |
| MW: | 552.6 D |
ab 54,00 €
