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GSK-J1
Artikelnummer: TGM-T6847-100mg
Description: GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >10-fold selectivity over other tested demethylases. Target: Histone Demethylase. Smiles: OC(=O)CCNc1cc(nc(n1)-c1ccccn1)N1CCc2ccccc2CC1....
| Schlagworte: | GSK J1 |
| Anwendung: | pan-HDAC inhibitor (HDAC1, 2, 4, 10, 11) |
| CAS | 1373422-53-7 |
| MW: | 389.45 D |
ab 42,00 €
GSK-J1
Artikelnummer: SYN-3030-M001
GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other...
| Schlagworte: | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine |
| Anwendung: | H3K27 histone demethylase JMJD3 (KDM6B) / UTX (KDM6A) inhibitor |
| CAS | 1373422-53-7 |
| MW: | 389.5 D |
ab 92,00 €
Quisinostat
Artikelnummer: SYN-3029-M100
Quisinostat (JNJ-26481585) is a novel second-generation panHDAC inhibitor of HDAC1, 2, 4, 10 and 11. Its highest potency is against HDAC1 with an IC50 of 0.11nM. It has only modest potency against HDACs 2, 4, 10, and 11 (IC50 ranging from 0.33nM to 0.64nM). It has low activity against HDACs 3, 5, 8, and 9 and its...
| Schlagworte: | JNJ-26481585 |
| Anwendung: | pan-HDAC inhibitor (HDAC1, 2, 4, 10, 11) |
| CAS | 1373422-53-7 |
| MW: | 394.5 D |
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