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GNE-617
Artikelnummer: TGM-T4335-100mg
Description: GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer. Target: NAMPT. Smiles: Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1. References: Shames DS, et al. Loss of NAPRT1 Expression by Tumor-specific Promoter Methylation Provides a Novel Predictive Biomarker...
| Schlagworte: | GNE617 |
| Anwendung: | NAMPT inhibitor |
| CAS | 1362154-70-8 |
| MW: | 427.42 D |
ab 34,00 €
GNE-617
Artikelnummer: Cay22463-1
GNE-617 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt, IC50 = 5 nM). It has antiproliferative activity in U251 glioblastoma, HT-1080 fibrosarcoma, PC3 prostate, MiaPaCa2 pancreatic, and HCT116 colon cancer cell lines (IC50s = 1.8, 2.1, 2.7, 7.4, and 2.0 nM, respectively). In a U251 mouse...
| Schlagworte: | N-[[4-[(3,5-difluorophenyl)sulfonyl]phenyl]methyl]-imidazo[1,2-a]pyridine-6-carboxamide |
| Anwendung: | NAMPT inhibitor |
| CAS | 1362154-70-8 |
| MW: | 427.4 D |
ab 46,00 €
