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ML-210
Artikelnummer: TGM-T8375-100mg
Description: ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis. Target: Glutathione Peroxidase, Ferroptosis, Ras, GPX. Smiles: Cc1onc(C(=O)N2CCN(CC2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1[N+]([O-])=O....
| Schlagworte: | CID 49766530 |
| Anwendung: | HRas(G12V)-expressing cell specific cytotoxin |
| CAS | 1360705-96-9 |
| MW: | 475.32 D |
ab 34,00 €
ML-210
Artikelnummer: Cay23282-1
ML-210 is an inhibitor of glutathione peroxidase 4 (GPX4). It reduces viability of mesenchymal-state KP4 cells, an effect that can be blocked by the arachidonic acid lipoxygenase inhibitors PD 146176 (Cay-10010518) and zileuton (Cay-10006967). It is also selectively lethal to mutant RAS oncogene-expressing cells...
| Schlagworte: | DPI10, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone |
| Anwendung: | HRas(G12V)-expressing cell specific cytotoxin |
| CAS | 1360705-96-9 |
| MW: | 475.3 D |
ab 43,00 €
