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Fluzoparib
Artikelnummer: TGM-T8806-100mg
Description: Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours. Target: PARP. Smiles: Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCn2nc(nc2C1)C(F)(F)F. References: Wang L , Yang C , Xie C , et al. Pharmacologic characterization of fluzoparib,...
| Schlagworte: | HS10160, SHR3162 |
| Anwendung: | PARP1 inhibitor |
| CAS | 1358715-18-0 |
| MW: | 472.4 D |
ab 54,00 €
Fluzoparib
Artikelnummer: Cay36671-10
Fluzoparib is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1, IC50 = 1.46 nM). It induces DNA double-strand breaks in wild-type, but not BRCA2-/-, V-C8 cells, as well as BRCA1-/- MDA-MB-436 cells when used at concentrations of 1 and 10 µM. Fluzoparib inhibits the proliferation of BRCA2-/- V-C8 cells (IC50 =...
| Schlagworte: | 4-[[3-[[5,6-dihydro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phtha... |
| Anwendung: | PARP1 inhibitor |
| CAS | 1358715-18-0 |
| MW: | 472.4 D |
ab 267,00 €
