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ON123300
Artikelnummer: TGM-T6920-100mg
Description: ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRbeta/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM). Target: Src, AMPK, CDK, c-RET, PDGFR, JAK, FGFR. Smiles: CN1CCN(CC1)c1ccc(Nc2ncc3cc(C#N)c(=O)n(C4CCCC4)c3n2)cc1. References: Divakar SK, et al .Leukemia. 2016 Jan,30(1):86-93.
| Anwendung: | CDK inhibitor |
| CAS | 1357470-29-1 |
| MW: | 429.52 D |
ab 40,00 €
ON-123300
Artikelnummer: Cay19902-1
ON-123300 is a multi-kinase inhibitor. It inhibits ARK5, Cdk4, and Cdk6 (IC50s = 3.87, 9.82, and 4.95 nM, respectively) as well as FYN, PDGFRbeta, Abl, and PI3Kdelta (IC50s = 11.09, 26, 53.32, and 144 nM, respectively) among others. It inhibits proliferation in a panel of 38 cancer cell lines (GI50s = 0.05-5 µM)....
| Schlagworte: | 8-cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonitrile |
| Anwendung: | CDK inhibitor |
| CAS | 1357470-29-1 |
| MW: | 429.5 D |
ab 52,00 €
