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Tirabrutinib
Artikelnummer: TGM-TQ0236-100mg
Description: Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton's Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and inhibits aberrant B cell receptor signaling. Tirabrutinib can be used in studies of...
| Schlagworte: | ONO-4059, Velexbru, GS-4059 |
| Anwendung: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| CAS | 1351636-18-4 |
| MW: | 454.48 D |
ab 41,00 €
ONO-4059
Artikelnummer: Cay32957-5
ONO-4059 is an inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 2.2 nM). It is selective for BTK over LCK, LYN, and Fyn at 1 µM. ONO-4059 inhibits B cell proliferation and activation in vitro and reduces tumor growth in a TMD8 mouse xenograft model.Formal Name:...
| Schlagworte: | GS-4059, ONO-WG-307, Tirabrutinib,... |
| Anwendung: | BTK inhibitor |
| CAS | 1351636-18-4 |
| MW: | 454.5 D |
ab 86,00 €
