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GSK-872
Artikelnummer: TGM-T4074-100mg
Description: GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM). Target: RIP kinase. Smiles: CC(C)S(=O)(=O)c1ccc2nccc(Nc3ccc4scnc4c3)c2c1. References: Mandal P, et al. RIP3 induces...
| Schlagworte: | GSK872, GSK2399872A, GSK'872 |
| Anwendung: | RIPK3 inhibitor |
| CAS | 1346546-69-7 |
| MW: | 383.49 D |
ab 33,00 €
GSK872
Artikelnummer: Cay23300-1
GSK872 is an inhibitor of receptor-interacting protein kinase 3 (RIPK3). It is selective for RIPK3, having >1,000-fold selectivity over 300 kinases in a fluorescence polarization assay at a concentration of 1 µM. GSK872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts. It also inhibits necrosis induced...
| Schlagworte: | N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine |
| Anwendung: | RIPK3 inhibitor |
| CAS | 1346546-69-7 |
| MW: | 383.5 D |
ab 44,00 €
