Zu "1345675-25-3" wurden 2 Artikel gefunden!
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E6446 dihydrochloride
Artikelnummer: TGM-T4068-100mg
Description: E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs, potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM. Target: TLR. Smiles: Cl.Cl.C(COc1ccc(cc1)-c1nc2ccc(OCCCN3CCCC3)cc2o1)CN1CCCC1. References: Lamphier M, et al. Novel small molecule inhibitors of...
| Anwendung: | TLR7 / TLR9 antagonist |
| CAS | 1345675-25-3 |
| MW: | 522.51 D |
ab 109,00 €
E6446 (hydrochloride)
Artikelnummer: Cay37296-1
E6446 is an antagonist of toll-like receptor 7 (TLR7) and TLR9 (IC50s = 1.78 and 0.01 µM, respectively). It is selective for TLR7 and TLR9 over TLR4 (IC50 = 10.58 µM). E6446 inhibits IL-6 production induced by the TLR9 agonist CpG ODN2216 or TLR7 agonist RNA40 in isolated mouse bone marrow-derived dendritic cells...
| Schlagworte: | 6-[3-(1-pyrrolidinyl)propoxy]-2-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-benzoxazole, dihydrochloride |
| Anwendung: | TLR7 / TLR9 antagonist |
| CAS | 1345675-25-3 |
| MW: | 522.5 D |
ab 103,00 €
