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Citarinostat
Artikelnummer: TGM-T3661-100mg
Description: ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activity of HDACs, this results in an accumulation of highly acetylated chromatin...
| Schlagworte: | ACY241, HDAC-IN-2 |
| Anwendung: | Targets histone deacetylase 6 [EC:3.5.1.98] (HDAC6) |
| CAS | 1316215-12-9 |
| MW: | 467.95 D |
ab 45,00 €
ACY-241
Artikelnummer: Cay26173-10
ACY-241 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 2.6 nM). It is selective for HDAC6 over HDAC1-3, HDAC7, and HDAC9 (IC50s = 35, 45, 46, 7,300, and 137 nM, respectively), as well as HDAC4, HDAC5, and HDAC9 (IC50 = >20,000 nM for all). It reduces proliferation of A2780, TOV-21G, and MDA-MB-231 cells...
| Schlagworte: | Citarinostat, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1316215-12-9 |
| MW: | 468 D |
ab 117,00 €
