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Miransertib
Artikelnummer: TGM-T3467-100mg
Description: Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor. Target: Akt, Parasite. Smiles: Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1ccccc1. References: Yu Y, et al. PLoS One. 2015, 10(10):e20140479.
| Schlagworte: | AKT inhibitor 2, ARQ-092 |
| Anwendung: | Targets RAC serine/threonine-protein kinase [EC:2.7.11.1] (AKT) |
| CAS | 1313881-70-7 |
| MW: | 432.52 D |
ab 44,00 €
ARQ 092
Artikelnummer: Cay21388-1
ARQ 092 is an allosteric, orally bioavailable, pan-Akt inhibitor (IC50s = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). It is selective for Akt isoforms over a panel of 303 other kinases. ARQ 092 binds inactive Akt and prevents membrane localization and full Akt activation. It also directly inhibits...
| Schlagworte: | 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-2-pyridinamine |
| Anwendung: | AKT inhibitor |
| CAS | 1313881-70-7 |
| MW: | 432.5 D |
ab 60,00 €
