Zu "1311367-27-7" wurden 4 Artikel gefunden!
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BIX 02565
Artikelnummer: TGM-T5428-10mg
Description: BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM). Target: LRRK2, S6 Kinase. Smiles: C[C@@H]1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C. References: Kirrane TM, et al. Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity. Bioorg Med...
| Anwendung: | RSK2 inhibitor |
| CAS | 1311367-27-7 |
| MW: | 458.56 D |
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BIX 02565
Artikelnummer: Cay19183-1
The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility. Phosphorylation of the sodium-hydrogen exchanger (NHE) in cardiac tissue by RSK has been shown to activate NHE during cellular stresses, such as myocardial...
| Schlagworte: | (5R)-N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole... |
| Anwendung: | RSK2 inhibitor |
| CAS | 1311367-27-7 |
| MW: | 458.6 D |
ab 49,00 €
MBP146-78
Artikelnummer: SYN-1227-M100
MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo. The molecular target of MBP146-78 was identified as cGMP-dependent protein kinase (PKG) using a tritiated analogue to purify a approximately 120-kDa protein from lysates of Eimeria tenella. This represents the first example of a protozoal PKG....
| Schlagworte: | 4-[2-(4-Fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl] pyridine |
| Anwendung: | Eimeria spp. cGMP-dependent protein kinase (PKG) inhibitor |
| CAS | 1311367-27-7 |
| MW: | 335.4 D |
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BIX02565
Artikelnummer: SYN-1228-M001
Solid. Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water. TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC(50) of 2.4nM.
| Schlagworte: | TAK632 |
| Anwendung: | pan-RAF inhibitor |
| CAS | 1311367-27-7 |
| MW: | 554,5 D |
ab 139,00 €
