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PLX5622
Artikelnummer: TGM-T7100-100mg
Description: PLX5622 is a highly selective, brain-penetrant, and orally active CSF1R inhibitor. Target: c-Fms, CSF-1R. Smiles: COc1ncc(F)cc1CNc1ccc(Cc2c[nH]c3ncc(C)cc23)c(F)n1. References: Rosin JM, Vora SR, Kurrasch DM.Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific...
| Schlagworte: | PLX-5622 |
| Anwendung: | CSF1R inhibitor |
| CAS | 1303420-67-8 |
| MW: | 395.41 D |
ab 84,00 €
PLX5622
Artikelnummer: Cay28927-1
PLX5622 is a brain-penetrant inhibitor of the colony stimulating factor 1 receptor (CSF1R, IC50 = 0.016 µM). It is selective for CSF1R over FMS-related tyrosine kinase 3 (FLT3), Kit, Aurora C, and kinase insert domain receptor (VEGFR2, IC50s = 0.39, 0.86, 1, and 1.1 µM, respectively) and is greater than 100-fold...
| Schlagworte: | 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine |
| Anwendung: | CSF1R inhibitor |
| CAS | 1303420-67-8 |
| MW: | 395.4 D |
ab 35,00 €
