Zu "1287665-60-4" wurden 2 Artikel gefunden!
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AS-2444697
Artikelnummer: TGM-T4299-100mg
Description: AS-2444697 is an inhibitor of IRAK-4 (C50 = 21 nM). AS-2444697 exhibits renoprotective effects through anti-inflammatory action. AS-2444697 potently inhibits human and rat IRAK-4 activity. Target: IRAK. Smiles: Cl.Cc1cc(ccn1)-c1nc(co1)C(=O)Nc1cn(nc1C(N)=O)C1CCOCC1. References: Mitsuhiro Kondo, et al....
| Anwendung: | IRAK4 inhibitor |
| CAS | 1287665-60-4 |
| MW: | 432.86 D |
ab 40,00 €
AS-2444697 (hydrochloride)
Artikelnummer: Cay29505-1
AS-2444697 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4, IC50 = 21 nM). It is greater than 30-fold selective for IRAK4 over a panel of 146 kinases, but is less than 10-fold selective over PDGFRalpha, PDGFRbeta, TrkA, TrkC, CLK1, Itk, and FLT3. AS-2444697 inhibits IL-1beta-induced IL-6...
| Schlagworte: | N-[3-(aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide,... |
| Anwendung: | IRAK4 inhibitor |
| CAS | 1287665-60-4 |
| MW: | 432.9 D |
ab 47,00 €
