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BMS-813160
Artikelnummer: TGM-T4584-100mg
Description: BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular. Target: CCR. Smiles: CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(nn23)C(C)(C)C)C1=O)NC(C)(C)C. References: Norman P. et al. A dual CCR2/CCR5 chemokine antagonist, BMS-813160? Evaluation of...
| Schlagworte: | BMS 813160 |
| Anwendung: | CCR2/CCR5 dual antagonist |
| CAS | 1286279-29-5 |
| MW: | 484.64 D |
ab 56,00 €
BMS 813160
Artikelnummer: Cay28421-1
BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC50s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1beta in isolated peripheral T cells with IC50 values of 0.8 and 1.1 nM,...
| Schlagworte: | N-[(1R,2S,5R)-5-[(1,1-dimethylethyl)amino]-2-[(3S)-3-[[7-(1,1-dimethylethyl)pyrazolo[1,5-a]-1,3,5-triazin-4-yl]amino]-2-ox... |
| Anwendung: | CCR2/CCR5 dual antagonist |
| CAS | 1286279-29-5 |
| MW: | 484.6 D |
ab 324,00 €
