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MI-3
Artikelnummer: TGM-T2643-10mg
Description: MI-3 (Menin-MLL Inhibitor) (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM). Target: Apoptosis, Histone Methyltransferase, Epigenetic Reader Domain. Smiles: CC(C)c1cc2c(ncnc2s1)N1CCN(CC1)C1=NCC(C)(C)S1. References: Grembecka J, et al. Nat Chem Biol. 2012, 8(3),...
| Schlagworte: | Menin-MLL Inhibitor, Menin-MLL inhibitor 3, MI 3 |
| CAS | 1271738-59-0 |
| MW: | 375.55 D |
ab 46,00 €
MI-3
Artikelnummer: Cay27214-1
MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 648 nM). MI-3 binds to menin (Kd = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of...
| Schlagworte: | 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)-thieno[2,3-d]pyrimidine |
| Anwendung: | MLL / menin interaction inhibitor |
| CAS | 1271738-59-0 |
| MW: | 375.6 D |
ab 52,00 €
