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NMS-P118
Artikelnummer: TGM-T4472-100mg
Description: NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy. Target: PARP. Smiles: NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12. References: Papeo G, et al. Discovery of...
| Anwendung: | PARP-1 inhibitor |
| CAS | 1262417-51-5 |
| MW: | 395.42 D |
ab 37,00 €
NMS-P118
Artikelnummer: Cay21340-5
NMS-P118 is an orally bioavailable, potent, and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1), which is an enzyme activated by DNA damage and is critical for the repair of DNA single-strand breaks via the base excision repair pathway. NMS-P118 is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390...
| Schlagworte: | 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide |
| Anwendung: | PARP-1 inhibitor |
| CAS | 1262417-51-5 |
| MW: | 395.4 D |
ab 50,00 €
