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CEP-33779
Artikelnummer: TGM-T6122-100mg
Description: CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM. Target: JAK. Smiles: CN1CCN(CC1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1. References: Stump KL, et al. Arthritis Res Ther, 2011, 13(2), R68.
| Schlagworte: | CEP33779 |
| Anwendung: | JAK2 inhibitor |
| CAS | 1257704-57-6 |
| MW: | 462.57 D |
ab 38,00 €
CEP-33779
Artikelnummer: Cay16732-500
Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription family. CEP-33779 is a potent, orally available inhibitor of JAK2 (IC50 = 1.3 nM). It shows 65-fold selectivity for JAK2 over JAK3. In mouse models...
| Schlagworte: | N-[3-(4-methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine |
| Anwendung: | JAK2 inhibitor |
| CAS | 1257704-57-6 |
| MW: | 462.6 D |
ab 92,00 €
