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THPP-1
Artikelnummer: TGM-T8506-100mg
Description: THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively). Target: PDE. Smiles: COCCOc1nc(nc2CCN(Cc12)C(=O)c1ncn2ccccc12)-c1ccc(Cl)nc1. References: Vardigan JD, et al. Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel...
| Anwendung: | PDE10A inhibitor |
| CAS | 1257051-63-0 |
| MW: | 464.9 D |
ab 34,00 €
THPP-1
Artikelnummer: Cay34219-1
THPP-1 is an inhibitor of phosphodiesterase 10A (PDE10A, Ki = 1 nM). It is selective for PDE10A over PDE1A-9A and PDE11A (Kis = 44->50,000 nM for all). THPP-1 (3 mg/kg) decreases the number of avoidances in the conditioned avoidance response test in rats and reduces MK-801-induced increases in locomotor activity in...
| Schlagworte: | [2-(6-chloro-3-pyridinyl)-7,8-dihydro-4-(2-methoxyethoxy)pyrido[4,3-d]pyrimidin-6(5H)-yl]imidazo[1,5-a]pyridin-1-yl-methanone |
| Anwendung: | PDE10A inhibitor |
| CAS | 1257051-63-0 |
| MW: | 464.9 D |
ab 111,00 €
