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JNJ-42153605
Artikelnummer: TGM-T3451-100mg
Description: JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM). Target: GluR. Smiles: FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1. References: Cid JM, et al. Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a...
| Anwendung: | Positive allosteric mGlu2 receptor modulator |
| CAS | 1254977-87-1 |
| MW: | 400.44 D |
ab 30,00 €
JNJ-42153605
Artikelnummer: Cay21984-1
JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2, EC50 = 17 nM in CHO cells expressing the human receptor). In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50...
| Schlagworte: | 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine |
| Anwendung: | Positive allosteric mGlu2 receptor modulator |
| CAS | 1254977-87-1 |
| MW: | 400.4 D |
ab 52,00 €
