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ETP-46321
Artikelnummer: TGM-TQ0229-100mg
Description: ETP-46321 is an effective and orally bioavailable PI3Kalpha/PI3Kdelta inhibitor (Ki: 2.3/14.2 nM). Target: PI3K. Smiles: CS(=O)(=O)N1CCN(Cc2cn3cc(nc(N4CCOCC4)c3n2)-c2cnc(N)nc2)CC1. References: Martínez González S, et al. Identification of ETP-46321, a potent and orally bioavailable PI3K alpha, delta...
| Anwendung: | PI3K p110alpha / p110delta inhibitor |
| CAS | 1252594-99-2 |
| MW: | 473.55 D |
ab 79,00 €
ETP-46321
Artikelnummer: Cay37330-1
ETP-46321 is an inhibitor of PI3K p110alpha and p110delta (apparent Kis = 2.3 and 14.2 nM, respectively). It is selective for PI3K p110alpha and p110delta over p110beta and p110gamma (apparent Kis = 170 and 179 nM, respectively), as well as a panel of 288 kinases at 1 µM. ETP-46321 inhibits Akt phosphorylation in...
| Schlagworte: | 5-[2-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]-2-pyrimidinamine |
| Anwendung: | PI3K p110alpha / p110delta inhibitor |
| CAS | 1252594-99-2 |
| MW: | 473.6 D |
ab 69,00 €
