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Tubastatin A
Artikelnummer: Cay15785-5
Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces alpha-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a...
| Schlagworte: | N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-benzamide |
| Anwendung: | Potent HDAC6 inhibitor |
| CAS | 1252003-15-8 |
| MW: | 335.4 D |
ab 60,00 €
Tubastatin A
Artikelnummer: AG-CR1-3900-M010
Off-white solid. Soluble in DMSO. Cell permeable potent and selective class IIb histone deacetylase 6 (HDAC6) inhibitor (IC50=15nM, >,1000-fold selective against other HDACs and 60-fold for HDAC8), Neuroprotective. Effectively prevents neuronal cell death (by &ge,95% at 10µ,M) upon oxidative stress induction...
| Schlagworte: | N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl] benzamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1252003-15-8 |
| MW: | 335,4 D |
72,00 €
