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CC-115
Artikelnummer: TGM-T3541-100mg
Description: CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). Target: DNA-PK, PI3K, mTOR. Smiles: CCN1C(=O)CNc2ncc(nc12)-c1ccc(nc1C)-c1ncn[nH]1. References: Thijssen R, et al. Blood. 2016, 128(4):574-83.
| Schlagworte: | CC 115 |
| Anwendung: | DNA-PK / mTOR inhibitor |
| CAS | 1228013-15-7 |
| MW: | 336.35 D |
ab 40,00 €
CC-115
Artikelnummer: Cay19420-1
CC-115 is a dual inhibitor of mammalian target of rapamycin (mTOR) and DNA protein kinase (DNA-PK, IC50s = 0.021 and 0.013 µM, respectively). It is selective for mTOR and DNA-PK over PI3Kalpha, ATM, and ATR (IC50s = 0.85, >30, and >30 µM, respectively). CC-115 inhibits growth in a panel of 123 cancer cell lines,...
| Schlagworte: | 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-pyrazino[2,3-b]pyrazin-2(1H)-one |
| Anwendung: | DNA-PK / mTOR inhibitor |
| CAS | 1228013-15-7 |
| MW: | 336.4 D |
ab 44,00 €
