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AZD3839 free base
Artikelnummer: TGM-T6772-10mg
Description: AZD3839 free base is a potent and selective BACE1 inhibitor with a Ki of 26.1 nM, demonstrating approximately 14-fold selectivity over BACE2. [Phase 1]. Target: Beta-Secretase, BACE. Smiles: NC1=N[C@@](c2cccc(F)c12)(c1cccc(c1)-c1cncnc1)c1ccnc(c1)C(F)F. References: Jeppsson F, et al. J Biol Chem. 2012,...
| Schlagworte: | AZD3839 |
| Anwendung: | BACE1 inhibitor |
| CAS | 1227163-84-9 |
| MW: | 431.41 D |
ab 48,00 €
AZD 3839
Artikelnummer: Cay28388-1
AZD 3839 is an inhibitor of beta-secretase 1 (BACE1). It selectively binds to BACE1 over BACE2 (Kis = 26.1 and 372.4 nM, respectively, for the human enzymes). It also inhibits human ether-a-go-go-related gene (hERG) potassium channels expressed in CHO cells (IC50 = 4.8 µM). AZD 3839 decreases amyloid-beta (Abeta)...
| Schlagworte: | (1S)-1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-1H-isoindol-3-amine |
| Anwendung: | BACE1 inhibitor |
| CAS | 1227163-84-9 |
| MW: | 431.4 D |
ab 61,00 €
