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PF-9184
Artikelnummer: TGM-T21738-10mg
Description: PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 16.5 nM, and it inhibits IL-1beta-induced PGE2 synthesis in vitro. Target: Prostaglandin Receptor. Smiles: OC1=C(NS(=O)(=O)c2ccccc12)C(=O)Nc1ccc(cc1)-c1ccc(Cl)c(Cl)c1. References: Gabriel...
| CAS | 1221971-47-6 |
| MW: | 461.32 D |
ab 31,00 €
PF-9184
Artikelnummer: Cay18904-1
Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product prostaglandin H2 (PGH2, Cay-17020) into the biologically active PGE2 (Cay-14010). Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1beta, and TNF-alpha. PF-9184 is a potent inhibitor...
| Schlagworte: | N-(3',4'-dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
| Anwendung: | mPGES-1 inhibitor |
| CAS | 1221971-47-6 |
| MW: | 461.3 D |
ab 60,00 €
