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Talazoparib
Artikelnummer: TGM-T6253-100mg
Description: Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM). Target: PARP. Smiles: Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1. References: Wilkerson PM, et al. Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of...
| Schlagworte: | LT-673, BMN-673 |
| Anwendung: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 1207456-01-6 |
| MW: | 380.35 D |
ab 37,00 €
BMN 673
Artikelnummer: Cay19782-1
BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of 0.57 nM. It similarly binds to PARP1 and PARP2 with Ki values of 1.2 and 0.85 nM, respectively, but has no effect on PARG. BMN 673 selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits...
| Schlagworte: | Talazoparib,... |
| Anwendung: | Antineoplastic, PARP inhibitor |
| CAS | 1207456-01-6 |
| MW: | 380.4 D |
ab 99,00 €
