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Epacadostat
Artikelnummer: TGM-T3548-100mg
Description: Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reducing tumor-associated regulatory T cells. Target: Indoleamine 2,3-Dioxygenase (IDO), IDO. Smiles:...
| Schlagworte: | IDO Inhibitor 1, INCB 024360 |
| Anwendung: | Targets indoleamine 2,3-dioxygenase [EC:1.13.11.52] (IDO, INDO) |
| CAS | 1204669-58-8 |
| MW: | 438.23 D |
ab 39,00 €
Epacadostat
Artikelnummer: Cay19875-1
Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with an IC50 value of 7.1 nM in HeLa cells that demonstrates little activity against the related enzymes IDO2 or tryptophan 2,3-dioxygenase (TDO). It has been shown to promote T and natural killer-cell growth, to increase IFN-gamma production, and...
| Schlagworte: | INCB024360,... |
| Anwendung: | IDO1 inhibitor |
| CAS | 1204669-58-8 |
| MW: | 438.2 D |
ab 43,00 €
Epacadostat
Artikelnummer: AG-CR1-3634-M005
White to off-white solid. Soluble in DMSO (~30mg/ml). Insoluble in water. Potent and selective competitive indoleamine 2,3-dioxygenase (IDO1) inhibitor. Inhibits IDO1 in enzymatic (IC50=72nM) and in cellular tests (IC50=7.1nM), suppresses tryptophan catabolism in vivo and impedes tumor growth. Displays high...
| Schlagworte: | INCB24360, (E)-N'-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-((2-(sulfamoylamino-1,2,5-oxadiazole-3-carboxamide) |
| Anwendung: | Potent and selective competitive IDO1 inhibitor |
| CAS | 1204669-58-8 |
| MW: | 438,2 D |
ab 132,00 €
