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Dabrafenib
Artikelnummer: TGM-T1903-1mL
Description: Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma. Target: Raf. Smiles: CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F....
| Schlagworte: | GSK2118436A, GSK2118436 |
| Anwendung: | Targets B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] (BRAF) |
| CAS | 1195765-45-7 |
| MW: | 519.56 D |
ab 42,00 €
Dabrafenib
Artikelnummer: Cay16989-5
Dabrafenib is an ATP-competitive inhibitor of Raf kinases (IC50s = 0.64, 0.68, and 5 nM for wild-type B-RAF kinase, mutant B-RAFV600E, and wild-type C-RAF kinase, respectively). It also inhibits the tyrosine kinase-like kinases ALK5 and LIMK1 (IC50s = 11 and 15 nM, respectively) and the calcium/calmodulin-dependent...
| Schlagworte: | GSK2118436,... |
| Anwendung: | B-Raf V600E inhibitor |
| CAS | 1195765-45-7 |
| MW: | 519.6 D |
ab 49,00 €
Dabrafenib
Artikelnummer: LKT-D0004.5
A potent ATP-competitive inhibitor of b-Raf, b-Raf(V600E) and c-Raf.
| Schlagworte: | N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide |
| Anwendung: | B-Raf / B-Raf (V600E) / c-Raf inhibitor |
| CAS | 1195765-45-7 |
| MW: | 519.56 D |
ab 126,00 €
