Zu "1194044-20-6" wurden 2 Artikel gefunden!
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LY2811376
Artikelnummer: TGM-T2639-100mg
Description: LY2811376, an orally available non-peptidic beta-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Abeta secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin....
| CAS | 1194044-20-6 |
| MW: | 320.36 D |
ab 48,00 €
LY2811376
Artikelnummer: Cay16712-1
Accumulation of the beta-amyloid (Abeta) peptide in the brain is implicated as the primary cause of neurodegeneration and progression of Alzheimer's disease. Abeta is derived from sequential proteolytic cleavage of the amyloid precursor protein (APP) by beta-secretase (BACE) and gamma-secretase. LY2811376 is a...
| Schlagworte: | (4S)-4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine |
| Anwendung: | BACE1 inhibitor |
| CAS | 1194044-20-6 |
| MW: | 320.4 D |
ab 61,00 €
