Zu "1168091-68-6" wurden 3 Artikel gefunden!
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GDC-0623
Artikelnummer: TGM-T6843-100mg
Description: GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1. Target: MEK, Apoptosis. Smiles: OCCONC(=O)c1ccc2cncn2c1Nc1ccc(I)cc1F. References: Hatzivassiliou G, et al. Nature. 2013, 501(7466), 232-236.
| Schlagworte: | MEK inhibitor 1, RG 7421, GDC0623, G-868 |
| Anwendung: | MEK1 inhibitor |
| CAS | 1168091-68-6 |
| MW: | 456.21 D |
ab 48,00 €
GDC-0623
Artikelnummer: LKT-G1210.1
GDC-0623 is an inhibitor of MEK that prevents MEK-dependent B-Raf and KRAS signaling. GDC-0623 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for several cancers.
| Anwendung: | MEK inhibitor |
| CAS | 1168091-68-6 |
| MW: | 456.21 D |
ab 69,00 €
GDC-0623
Artikelnummer: Cay19479-1
GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP). It inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines with EC50 values of 7 and 42 nM, respectively. GDC-0623 inhibits ERK and BIM phosphorylation resulting in upregulation and...
| Schlagworte: | 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-imidazo[1,5-a]pyridine-6-carboxamide |
| Anwendung: | MEK1 inhibitor |
| CAS | 1168091-68-6 |
| MW: | 456.2 D |
ab 56,00 €
