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TCS7010
Artikelnummer: TGM-T6767-100mg
Description: TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Target: Apoptosis, Aurora Kinase. Smiles: CCN1CCN(CC1)C(=O)Cc1ccc(Nc2ncc(F)c(Nc3ccc(cc3)C(=O)Nc3ccccc3Cl)n2)cc1....
| Schlagworte: | Aurora A Inhibitor I |
| Anwendung: | AURKA inhibitor |
| CAS | 1158838-45-9 |
| MW: | 588.07 D |
ab 31,00 €
Aurora A Inhibitor I
Artikelnummer: Cay21600-5
Aurora A inhibitor I is a potent and selective inhibitor of Aurora A kinase (IC50s = 3.4 and 3,400 nM for Aurora A and Aurora B, respectively). It prevents centrosome separation and reduces phosphorylated Aurora A, but not phosphorylated histone H3, levels at the centrosomes, indicating inhibition is specific to...
| Schlagworte: | N-(2-chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide |
| Anwendung: | AURKA inhibitor |
| CAS | 1158838-45-9 |
| MW: | 588.1 D |
ab 43,00 €
