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Dofetilide
Artikelnummer: TGM-T6476-100mg
Description: Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and...
| Schlagworte: | UK 68789, UK-68798, Tikosyn |
| Anwendung: | Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1) |
| CAS | 115256-11-6 |
| MW: | 441.56 D |
ab 49,00 €
Dofetilide
Artikelnummer: Cay15045-5
Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 µM, dofetilide has pro-arrhythmic activity,...
| Schlagworte: | Tikosyn, UK 68789, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide |
| Anwendung: | Voltage-gated potassium channel (KCNH2) blocker |
| CAS | 115256-11-6 |
| MW: | 441.6 D |
ab 62,00 €
