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SNS-314 Mesylate
Artikelnummer: TGM-T2617-100mg
Description: SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2. Target: Aurora Kinase. Smiles: CS(O)(=O)=O.Clc1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1. References: Oslob JD, et al. Bioorg Med Chem Lett,...
| Schlagworte: | SNS-314 |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 1146618-41-8 |
| MW: | 527.04 D |
ab 33,00 €
SNS-314 (mesylate)
Artikelnummer: Cay14974-1
SNS-314 is a pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively). In a panel of 219 kinases, SNS-314 also inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM). SNS-314 inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma...
| Schlagworte: | N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-urea, monomethanesulfonate |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 1146618-41-8 |
| MW: | 527 D |
ab 109,00 €
