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E7449
Artikelnummer: TGM-T4471-100mg
Description: E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ~50 and ~50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. Target: PARP, Others. Smiles: O=c1[nH][nH]c2nc(CN3Cc4ccccc4C3)nc3cccc1c23. References:...
| Schlagworte: | UNII-9X5A2QIA7C, Stenoparib |
| Anwendung: | PARP1 / PARP2 inhibitor |
| CAS | 1140964-99-3 |
| MW: | 317.34 D |
ab 38,00 €
E7449
Artikelnummer: Cay21658-5
E7449 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 1 and 1.2 nM, respectively) as well as tankyrase (TNKS) 1/2 (IC50s = 50-100 nM). It is selective for PARP1, PARP2, and TNKS1/2 over PARP3 and PARP6-15 (IC50s = >3 µM). E7449 binds to chromatin in a concentration-dependent manner and...
| Schlagworte: | 8-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-1,2-dihydro-3H-pyridazino[3,4,5-de]quinazolin-3-one |
| Anwendung: | PARP1 / PARP2 inhibitor |
| CAS | 1140964-99-3 |
| MW: | 317.3 D |
ab 43,00 €
