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CX-5461
Artikelnummer: Cay18392-1
CX-5461 is an inhibitor of ribosomal RNA (rRNA) synthesis. It selectively inhibits RNA polymerase I-driven transcription of rRNA in HCT116, A375, and MIA PaCa-2 tumor cells (IC50s = 142, 113, and 54 nM, respectively) without affecting RNA polymerase II (IC50 > 25µM), DNA replication, or protein translation. At 50...
| Schlagworte: | 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]naphthyridi... |
| Anwendung: | rRNA synthesis inhibitor |
| CAS | 1138549-36-6 |
| MW: | 513.6 D |
ab 60,00 €
CX-5461
Artikelnummer: SYN-3031-M001
Slightly soluble (<1mg/ml) in DMSO or ethanol. CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
| Schlagworte: | Chantix, Champix |
| Anwendung: | RNA polymerase I inhibitor |
| CAS | 1138549-36-6 |
| MW: | 513.6 D |
ab 119,00 €
