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PF-04620110
Artikelnummer: TGM-T6937-10mg
Description: PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. Target: Acyltransferase, Transferase. Smiles: Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12. References: Dow RL, et al. ACS Med Chem Lett. 2011, 2(5), 407-412.
| Schlagworte: | PF 04620110, PF04620110 |
| Anwendung: | DGAT1 inhibitor |
| CAS | 1109276-89-2 |
| MW: | 396.44 D |
ab 37,00 €
PF-04620110
Artikelnummer: Cay16425-10
Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides and has potential roles in obesity, diabetes, and atherosclerosis. PF-04620110 is a potent inhibitor of DGAT-1 (IC50 = 19 nM) that is without effect on DGAT-2. It has high oral bioavailability...
| Schlagworte: | trans-4-[4-(4-amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]-cyclohexaneacetic acid |
| Anwendung: | DGAT1 inhibitor |
| CAS | 1109276-89-2 |
| MW: | 396.4 D |
ab 123,00 €
