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Glasdegib
Artikelnummer: TGM-T6514-100mg
Description: Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2. Target: Smo, Hedgehog/Smoothened. Smiles: CN1CC[C@H](C[C@@H]1c1nc2ccccc2[nH]1)NC(=O)Nc1ccc(cc1)C#N. References: Munchhof MJ, et al. ACS Med Chem Lett. 2011, 3(2), 106-111.
| Schlagworte: | PF-04449913 |
| Anwendung: | Targets smoothened (SMO) |
| CAS | 1095173-27-5 |
| MW: | 374.44 D |
ab 37,00 €
PF-04449913
Artikelnummer: Cay9002936-1
PF-04449913 is an orally available Hedgehog pathway inhibitor that acts by binding Smoothened (Smo) and blocking signal transduction (IC50 = 5 nM). It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila...
| Schlagworte: | Glasdegib, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)-urea |
| Anwendung: | Hedgehog pathway inhibitor |
| CAS | 1095173-27-5 |
| MW: | 374.4 D |
ab 47,00 €
