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GSK1904529A
Artikelnummer: TGM-T6003-10mg
Description: GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) . Target: IGF-1R, Apoptosis, Raf, Syk, VEGFR. Smiles: CCc1cc(Nc2nccc(n2)-c2c(nc3ccccn23)-c2ccc(OC)c(c2)C(=O)Nc2c(F)cccc2F)c(OC)cc1N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O. References: Sabbatini P, et al. Clin Cancer Res,...
| Schlagworte: | GSK 4529 |
| Anwendung: | Insulin receptor / IGF-1R dual inhibitor |
| CAS | 1089283-49-7 |
| MW: | 851.96 D |
ab 36,00 €
GSK-1904529A
Artikelnummer: LKT-G7541.1
GSK-1904529A is an inhibitor of the insulin receptor (InsR) and IGF-1R that exhibits anticancer chemotherapeutic activity. In cellular and animal models of multiple myeloma and Ewing's sarcoma, GSK-1904529A induces cell cycle arrest and inhibits cell proliferation and tumor growth.
| Schlagworte: | GSK1904529A |
| Anwendung: | InsR / IGF-1R inhibitor |
| CAS | 1089283-49-7 |
| MW: | 851.96 D |
ab 164,00 €
GSK1904529A
Artikelnummer: Cay29155-1
GSK1904529A is a dual inhibitor of the insulin receptor (InsR) and insulin-like growth factor 1 receptor (IGF-1R) kinases (IC50s = 25 and 27 nM, respectively, in a cell-free assay). It selectively inhibits InsR and IGF-1R kinases over a panel of 45 serine/threonine and tyrosine kinases (IC50s = >1 µM for all)....
| Schlagworte: | N-(2,6-difluorophenyl)-5-[3-[2-[[5-ethyl-2-methoxy-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-p... |
| Anwendung: | Insulin receptor / IGF-1R dual inhibitor |
| CAS | 1089283-49-7 |
| MW: | 852 D |
ab 44,00 €
