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PF-04418948
Artikelnummer: TGM-T3306-100mg
Description: PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors, exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 µM. Inhibits PGE2-induced...
| Schlagworte: | PF 04418948, PF04418948 |
| Anwendung: | EP2 receptor antagonist |
| CAS | 1078166-57-0 |
| MW: | 409.41 D |
ab 40,00 €
PF-04418948
Artikelnummer: Cay15016-5
Prostaglandin E2 (PGE2) evokes distinct responses through four different 'E prostanoid' (EP) receptors. EP2 is a G protein-coupled receptor which signals preferentially through Gs proteins. PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM). It is over a thousand-fold less...
| Schlagworte: | 1-(4-fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid |
| Anwendung: | EP2 receptor antagonist |
| CAS | 1078166-57-0 |
| MW: | 409.4 D |
ab 131,00 €
