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LDN-193189
Artikelnummer: Cay11802-1
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-beta superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are...
| Schlagworte: | 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Anwendung: | BMP type I receptor inhibitor |
| CAS | 1062368-24-4 |
| MW: | 406.5 D |
ab 47,00 €
LDN193189
Artikelnummer: TGM-T1935-100mg
Description: LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6). Target: ALK, TGF-beta/Smad. Smiles: C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12. References: Yu PB, et al. BMP type I...
| Schlagworte: | DM-3189, LDN 193189, LDN-193189 |
| Anwendung: | BMP type I receptor inhibitor |
| CAS | 1062368-24-4 |
| MW: | 406.48 D |
ab 42,00 €
