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UPF 1069
Artikelnummer: TGM-T6181-100mg
Description: UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 µM). It is ~27-fold selective against PARP1. Target: PARP. Smiles: O=C(COc1cccc2c1cc[nH]c2=O)c1ccccc1. References: Moroni F, et al. Br J Pharmacol, 2009, 157(5), 854-862.
| Anwendung: | PARP inhibitor |
| CAS | 1048371-03-4 |
| MW: | 279.29 D |
ab 32,00 €
UPF-1069
Artikelnummer: Cay17760-1
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively). In rat models of...
| Schlagworte: | GKT237841, 5-(2-oxo-2-phenylethoxy)-1(2H)-isoquinolinone |
| Anwendung: | PARP inhibitor |
| CAS | 1048371-03-4 |
| MW: | 279.3 D |
ab 43,00 €
