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Niraparib tosylate
Artikelnummer: TGM-T6892-100mg
Description: Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. Target: Apoptosis, PARP. Smiles: Cc1ccc(cc1)S(O)(=O)=O.NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1. References: Wang L, et al. Invest New Drugs. 2012, 30(6):2113-20.
| Schlagworte: | MK 4827 tosylate, MK-4827 (tosylate), Niraparib (MK-4827) tosylate |
| Anwendung: | Antineoplastic |
| CAS | 1038915-73-9 |
| MW: | 492.59 D |
ab 38,00 €
MK-4827 (tosylate)
Artikelnummer: Cay20842-5
MK-4827 is an orally bioavailable inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 3.8 and 2.1 nM, respectively). It inhibits the proliferation of cancer cells carrying the breast cancer mutations BRCA1 and BRCA2 in vitro (IC50 values range from 10-100 nM) and has efficacy alone against a...
| Schlagworte: | Niraparib tosylate, 2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide, 4-methylbenzenesulfonate |
| Anwendung: | Antineoplastic |
| CAS | 1038915-73-9 |
| MW: | 492.6 D |
ab 62,00 €
MK-4827 tosylate
Artikelnummer: CDX-M0565-M010
White to off-white solid. Soluble in DMSO or DMF (both 20mg/ml). Sparingly soluble in ethanol (1mg/ml) or water (<1mg/ml). Chemical. CAS: 1038915-73-9. Formula: C19H20N4O . C7H8O3S. MW: 492.6. Synthetic. MK-4827 is an orally bioavailable inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s=3.8 and...
| Schlagworte: | Niraparib tosylate, (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4 methylbenzenesulfonate |
| CAS | 1038915-73-9 |
| MW: | 492,6 D |
ab 244,00 €
