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Lipid-based Drug Delivery-Tools
Sphingosine-1-phosphate (d18:1)
Artikelnummer: Cay62570-1
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi...
| Schlagworte: | S1P (d18:1), Sphingosine-1-Phosphoric Acid, 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate) |
| Anwendung: | Bioactive lipid assays |
| CAS | 26993-30-6 |
| MW: | 379.5 D |
ab 100,00 €
Lipid-based Drug Delivery-Tools
1-Palmitoyl-2-hydroxy-sn-glycero-3-PC
Artikelnummer: Cay10172-25
1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine. It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and...
| Schlagworte: | 16:0/0:0-PC, 1-Hexadecanoyl-sn-glycero-3-Phosphatidylcholine, 1-Hexadecanoyl-sn-glycero-3-Phosphocholine,... |
| Anwendung: | Bioactive lipid assays |
| CAS | 17364-16-8 |
| MW: | 495.6 D |
ab 61,00 €
Lipid-based Drug Delivery-Tools
1,2-Distearoyl-sn-glycero-3-PC
Artikelnummer: Cay15100-1
1,2-Distearoyl-sn-glycero-3-PC (1,2-DSPC) is a phospholipid containing the saturated long-chain (18:0) stearic acid inserted at the sn-1 and sn-2 positions. It is commonly used in the generation of micelles, liposomes, and other types of artificial membranes. The transition temperature of 1,2-DSPC is approximately...
| Schlagworte: | 1,2-Distearoyl-sn-glycero-3-Phosphocholine, 1,2-DSPC, Coatsome MC 8080, 1,2-distearoyl-sn-glycero-3-phosphatidylcholine |
| Anwendung: | Phospholipid |
| CAS | 816-94-4 |
| MW: | 790.2 D |
ab 69,00 €
Lipid-based Drug Delivery-Tools
1,2-Dimyristoyl-sn-glycero-3-PC
Artikelnummer: Cay15097-1
1,2-Dimyristoyl-sn-glycero-3-PC (DMPC) is a phospholipid containing 14:0 fatty acids at the sn-1 and sn-2 positions. It is a synthetic phosopholipid that has been used for liposome production in order to study the properties of lipid bilayer.Formal Name: 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine. CAS Number:...
| Schlagworte: | 1,2-Dimyristoyl-sn-glycero-3-Phosphocholine, 1,2-DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine |
| Anwendung: | Liposome production |
| CAS | 18194-24-6 |
| MW: | 677.9 D |
ab 66,00 €
Lipid-based Drug Delivery-Tools
C16 Sphingomyelin (d18:1/16:0)
Artikelnummer: Cay10007946-1
C16 Sphingomyelin is a naturally occurring sphingolipid. Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ, Cay-13104), as well as in the liver in mouse models of Niemann-Pick type C1 disease. Plasma levels of C16 sphingomyelin...
| Schlagworte: | N-Palmitoyl-D-erythro-Sphingosylphosphorylcholine, Palmitoyl Sphingomyelin, SM(d18:1/16:0), Sphingomyelin (d18:1/16:0),... |
| Anwendung: | Bioactive Lipid Assays |
| CAS | 6254-89-3 |
| MW: | 703 D |
ab 94,00 €
Lipid-based Drug Delivery-Tools
1-Palmitoyl-2-Oleoyl-sn-glycero-3-PC
Artikelnummer: Cay15102-100
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (1,2-POPC) is a phospholipid containing 16:0 and 18:1 fatty acids at the sn-1 and sn-2 positions, respectively. It belongs to a class of phospholipids that are a major component of biological membranes. This compound can be used for liposome production in order to study the...
| Schlagworte: | 1,2-POPC, 1-Palmitoyl-2-Oleoyl-sn-glycero-3-Phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine |
| Anwendung: | Liposome production |
| CAS | 26853-31-6 |
| MW: | 760.1 D |
ab 102,00 €
Lipid-based Drug Delivery-Tools
1,2-Dioleoyl-sn-glycero-3-PE
Artikelnummer: Cay15091-100
1,2-Dioleoyl-sn-glycero-3-PE (1,2-DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. The compound features the same diacylglycerol stereochemistry as that of the natural compound. 1,2-DOPE can be used as an emulsifier to facilitate DNA-liposome complex...
| Schlagworte: | 1,2-Dioleoyl-sn-glycero-3-Phosphoethanolamine, 1,2-DOPE, 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine |
| Anwendung: | Emulsifier |
| CAS | 4004-05-1 |
| MW: | 744.1 D |
ab 109,00 €
Lipid-based Drug Delivery-Tools
ALC-0159
Artikelnummer: Cay34336-25
ALC-0159 is a lipid excipient. Formulations containing ALC-0159 have been used in the development of lipid nanoparticles (LNPs) for the delivery of mRNA-based vaccines.Formal Name: alpha-[2-(ditetradecylamino)-2-oxoethyl]-omega-methoxy-poly(oxy-1,2-ethanediyl). CAS Number: 1849616-42-7. Synonyms:...
| Schlagworte: | alpha-[2-(ditetradecylamino)-2-oxoethyl]-omega-methoxy-poly(oxy-1,2-ethanediyl) |
| Anwendung: | Lipid excipient, mRNA-based vaccine delivery |
| CAS | 1849616-42-7 |
ab 129,00 €
Lipid-based Drug Delivery-Tools
LipidLaunch(TM) LNP-102 Exploration Kit
Artikelnummer: Cay35425-1
This kit, formerly known as Lipid Nanoparticle (LNP-102) Exploration Kit, has recently been renamed to join our line of research-ready LipidLaunch(TM) products for LNP applications. Cayman's LipidLaunch(TM) LNP-102 Exploration Kit is intended to serve as a starting point for laboratories to explore the feasibility...
| Anwendung: | SM-102-containing LNP preparation |
354,00 €
Lipid-based Drug Delivery-Tools
DLin-MC3-DMA
Artikelnummer: Cay34364-10
DLin-MC3-DMA is an ionizable cationic amino lipid (apparent pKa = 6.44) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Administration of Factor VII siRNA in DLin-MC3-DMA-containing LNPs reduces plasma Factor VII protein levels in mice. Formulations containing...
| Schlagworte: | MC3, 4-(dimethylamino)-butanoic acid, (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester |
| Anwendung: | Ionizable amino lipid |
| CAS | 1224606-06-7 |
| MW: | 642.1 D |
ab 32,00 €
Lipid-based Drug Delivery-Tools
1-Stearoyl-2-hydroxy-sn-glycero-3-PC
Artikelnummer: Cay15107-100
1-Stearoyl-2-hydroxy-sn-glycero-3-PC is a saturated lysophosphatidylcholine. It increases IL-1beta production in isolated human blood monocytes when used at a concentration of 12.5 µM. Plasma levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PC are decreased in patients with lung cancer.Formal Name:...
| Schlagworte: | 1-Octadecanoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine, 1-Stearoyl-2-hydroxy-sn-glycero-3-Phosphocholine,... |
| Anwendung: | Lysophosphatidylcholine |
| CAS | 19420-57-6 |
| MW: | 523.7 D |
ab 84,00 €
Lipid-based Drug Delivery-Tools
D-erythro Lysosphingomyelin (d18:1)
Artikelnummer: Cay10007947-1
D-erythro Lysosphingomyelin is a bioactive sphingolipid. It is an agonist of sphingosine-1-phosphate receptor 1 (S1P1), S1P2, and S1P3 (EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors). D-erythro Lysosphingomyelin is also an agonist of the orphan receptor ovarian cancer G protein-coupled...
| Schlagworte: | D-erythro Lyso SM(18:1), D-erythro Sphingosine-1-Phosphocholine (d18:1), D-erythro-Sphingophosphorylcholine,... |
| Anwendung: | Bioactive Lipid Assays |
| CAS | 1670-26-4 |
| MW: | 464.6 D |
ab 121,00 €