Zu "925," wurden 27 Artikel gefunden!
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AMG 925 HCl
Artikelnummer: TGM-T63487-500mg
Description: AMG 925 HCl is a selective and potent dual inhibitor of FLT3 (IC50: 2±1 nM) and CDK4 (IC50: 3±1 nM). Target: Others. Smiles: N(C=1N=C2N(C=3C(C2=CN1)=CC=NC3)[C@H]4CC[C@H](C)CC4)C=5N=C6C(=CC5)CN(C(CO)=O)CC6.Cl
| CAS | 1401034-19-2 |
| MW: | 508.02 D |
1.167,00 €
AMG 925
Artikelnummer: TGM-T6756-10mg
Description: AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. Target: CDK, FLT. Smiles: C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCc4n3)C(=O)CO)nc12. References: Xiaoqi Chen, et al. Fused tricyclic dual inhibitors of cdk 4/6 and flt3. WO 2012129344 A1
| Anwendung: | FLT3 / Cdk4 dual inhibitor |
| CAS | 1401033-86-0 |
| MW: | 471.55 D |
ab 31,00 €
AMG 925
Artikelnummer: Cay29245-5
AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4, IC50s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC50 = 2.22 µM). AMG 925 also binds to FLT3ITD, FLT3D835Y, FLT3D835H, FLT3K663Q, and FLT3N841I (Kds = 1-4 nM). It inhibits...
| Schlagworte: | 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6... |
| Anwendung: | FLT3 / Cdk4 dual inhibitor |
| CAS | 1401033-86-0 |
| MW: | 471.6 D |
ab 43,00 €
ADR-925
Artikelnummer: TGM-T29670-5mg
Description: ADR-925 (ICRF 198), an active chelated iron metabolite of dexrazoxane, has the ability to protect neonatal rat cardiomyocytes from adriamycin-induced injury. Target: Endogenous Metabolite. Smiles: N([C@H](CN(CC(N)=O)CC(O)=O)C)(CC(N)=O)CC(O)=O. References: Jirkovský E, et al. Pharmacokinetics of the...
| Schlagworte: | ICRF198, ICRF-198, ICRF 198, ADR 925, ADR925 |
| CAS | 75459-34-6 |
| MW: | 304.3 D |
ab 1.098,00 €
Moexipril (hydrochloride)
Artikelnummer: Cay21255-10
Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for...
| Schlagworte: | CI-925, RS 10085-197, SPM 925,... |
| Anwendung: | ACE inhibitor |
| CAS | 82586-52-5 |
| MW: | 535 D |
ab 60,00 €
PathPlex(TM) Panel 7 (CD8 alpha, Cytokeratin, CD45RO,...
Artikelnummer: A810-007
PathPlex Panel 7 identifies total cytotoxic T-cells (CD8), T-helper cells (CD4), memory T-cells (CD45RO) and regulatory T-cells (FoxP3) within the context of the tumor microenvironment. Tumor cells are identified by cytokeratin.
| Schlagworte: | GeneID 925, 3858, 3861, 3866, 3868, 3880, 5788, 920, 50943 |
| Anwendung: | IHC-IF, MIF |
| Spezies-Reaktivität: | human |
2.360,00 €
PathPlex(TM) Panel 4 (CD3E, Cytokeratin, CD8 alpha, CD68,...
Artikelnummer: A810-004
PathPlex Panel 4 identifies total T-cells (CD3), cytotoxic T-cells (CD8) and regulatory T-cells (FoxP3) within the context of the tumor microenvironment. Antigen presenting cells such as macrophages (CD68) or tumor cells (cytokeratin) express immune checkpoint ligands such as PD-L1 which inhibits the ability of...
| Schlagworte: | GeneID 916, 925, 968, 29126, 50943, 3858, 3861, 3866, 3868, 3880 |
| Anwendung: | IHC-IF, MIF |
| Spezies-Reaktivität: | human |
2.833,00 €
PathPlex(TM) Panel 5 (CD3E, Cytokeratin, CD8 alpha, CD68,...
Artikelnummer: A810-005
PathPlex Panel 5 identifies total T-cells (CD3), cytotoxic T-cells (CD8) and cells expressing the immune checkpoint ligand PD-L1 within the context of the tumor microenvironment. PD-L1 can be expressed on antigen presenting cells such as macrophages (CD68) or tumor cells (cytokeratin). Ki-67 is a proliferation...
| Schlagworte: | GeneID 916, 925, 968, 4288, 29126, 3858, 3861, 3866, 3868, 3880 |
| Anwendung: | IHC-IF, MIF |
| Spezies-Reaktivität: | human |
2.833,00 €
PathPlex(TM) Panel 8 (CD3E, Cytokeratin, CD8 alpha, CD4,...
Artikelnummer: A810-008
PathPlex Panel 8 identifies total T-cells (CD3), T-helper cells (CD4), cytotoxic T-cells (CD8) and regulatory T-cells (FoxP3) within the tumor microenvironment. Lag3 is a checkpoint inhibitor which identifies exhausted T-cells. Tumor cells are identified by cytokeratin.
| Schlagworte: | GeneID 916, 3858, 3861, 3866, 3868, 3880, 925, 920, 3902, 50943 |
| Anwendung: | IHC-IF, MIF |
| Spezies-Reaktivität: | human |
2.833,00 €
PathPlex(TM) Panel 6 (CD3E, Granzyme B, CD8 alpha,...
Artikelnummer: A810-006
PathPlex Panel 6 identifies total T-cells (CD3) and cytotoxic T-cells (CD8) and activated cytotoxic T-cells (Granzyme B) within the tumor microenvironment. The inclusion of multiple tumor cell makers (cytokeratin, Sox10 and Ki-67) provides flexibility across multiple tumor types.
| Schlagworte: | GeneID 3880, 3868, 3866, 3861, 3858, 916, 3002, 925, 4288, 6663 |
| Anwendung: | IHC-IF, MIF |
| Spezies-Reaktivität: | human |
2.833,00 €
ABT-925 fumarate dihydrate
Artikelnummer: TGM-T29534-50mg
Description: ABT-925 is a selective dopamine D3 receptor (DRD3) antagonist with an in vitro affinity approximately 100 times higher for dopamine D3 receptors than for D2 receptors. Target: Others. Smiles: OC(/C=C/C(O)=O)=O.FC(F)(C1=CC(N2CCN(CC2)CCCSC(N3)=NC=CC3=O)=NC(C(C)(C)C)=N1)F.O.O. References: Pich EM, Collo G....
| Schlagworte: | ABT-925, BSF201640, DAT201, LU201640, ABT925, ABT 925 |
| CAS | 1160247-85-7 |
| MW: | 608.63 D |
ab 1.638,00 €
ABT-925 fumarate
Artikelnummer: TGM-T69808-100mg
Description: ABT-925, also known as A-37203, BSF-201640, DAT-201, Lu-201640, and A-437203, is a selective dopamine D3 receptor (DRD3) antagonist with an approximately 100-fold higher in vitro affinity for dopamine D3 versus D2 receptors. ABT-925 was tested in schizophrenia. ABT-925 is a selective dopamine D3...
| CAS | 220519-07-3 |
| MW: | 572.6 D |
ab 1.491,00 €