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AZ7550 hydrochloride
Artikelnummer: TGM-T13564L-1mg
Description: AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 µM). Target: EGFR, IGF-1R. Smiles: C=CC(NC1=CC(NC2=NC=CC(C3=CN(C4=C3C=CC=C4)C)=N2)=C(C=C1N(CCNC)C)OC)=O.[H]Cl. References: Finlay MR, et al. Discovery of a potent and selective EGFR...
| Schlagworte: | AZ7550 hydrochloride (1421373-99-0 free base) |
| CAS | 2309762-40-9 |
| MW: | 522.04 D |
ab 125,00 €
DIPQUO hydrochloride
Artikelnummer: TGM-T11048L-10mg
Description: DIPQUO hydrochloride is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 µM in C2C12 cells. DIPQUO hydrochloride promotes mouse and human osteoblast differentiation via activation of p38 MAPK-beta. Target: Phosphorylase. Smiles:...
| Schlagworte: | DIPQUO hydrochloride(1269365-82-3 Free base) |
| MW: | 351.83 D |
ab 63,00 €
EG01377 2HCl
Artikelnummer: TGM-T11154L-5mg
Description: EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 µM and an IC50 value of 609 nM for both EG01377 2HCl against NRP1-a1 and NRP1-b1.EG01377 exhibits anti-angiogenic, antimigratory and antitumor activities. Target: Complement System. Smiles:...
| Schlagworte: | EG01377 2HCl(2227996-00-9 Free base) |
| CAS | 2749438-61-5 |
| MW: | 659.6 D |
ab 147,00 €
JAK-IN-5 hydrochloride
Artikelnummer: TGM-T11710L-100mg
Description: JAK-IN-5 hydrochloride is a JAK inhibitor [1]. Target: JAK. Smiles: Cl.FC1=CC(C=2C=CC=3C(=NNC3C2)C4=NC5=C(N4)CCN(C5)C6CCN(C)CC6)=C(C=C1O)CC. References: Paul R. Fatheree, et al. JAK Kinase Inhibitor Compounds for Treatment of Respiratory Disease. US20170121327A1.
| Schlagworte: | JAK-IN-5 hydrochloride(2096999-92-5 Free base) |
| CAS | 2751323-21-2 |
| MW: | 511.03 D |
ab 1.620,00 €
JTV-519 Formate
Artikelnummer: TGM-T11731L-10mg
Description: JTV-519 Formate is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA). JTV-519 Formate is also a partial agonist of ryanodine receptors in striated muscle. JTV-519 Formate exhibits antiarrhythmic and cardioprotective properties. Target: Others, Calcium Channel. Smiles:...
| Schlagworte: | JTV-519 Formate (145903-06-6 Free base) |
| MW: | 470.62 D |
ab 194,00 €
Lesopitron HCl
Artikelnummer: TGM-T11839L-5mg
Description: Lesopitron HCl is a 5-HT1A receptor agonist with anxiolytic effects that reverses dark avoidance behavior associated with cocaine withdrawal in mice. Target: 5-HT Receptor. Smiles: Cl.ClC=1C=NN(C1)CCCCN2CCN(C3=NC=CC=N3)CC2. References: Glavin GB, et al. Effects of a novel 5-HT1A receptor agonist, E4424,...
| Schlagworte: | Lesopitron HCl(132449-89-9 Free base) |
| CAS | 132449-88-8 |
| MW: | 357.28 D |
ab 699,00 €
BRD 4354 ditrifluoroacetate
Artikelnummer: TGM-T10602-1mL
Description: BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 with IC50 values of 0.85 µM and 1.88 µM, respectively. Target: HDAC. Smiles: OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F. References: Boskovic ZV, ET AL. Inhibition of Zinc-Dependent...
| Schlagworte: | BRD 4354 ditrifluoroacetate (315698-07-8 free base) |
| MW: | 610.93 D |
88,00 €
Bucindolol Formate
Artikelnummer: TGM-T10631L-10mg
Description: Bucindolol Formatel is a blocker of beta1-adrenergic receptor. Bucindolol exhibits intrinsic sympathomimetic activity. Bucindolol can be used in the research of heart failure. Target: Adrenergic Receptor. Smiles: OC=O.CC(C)(Cc1c[nH]c2ccccc12)NCC(O)COc1ccccc1C#N. References: Stephen B Liggett, et al. A...
| Schlagworte: | Bucindolol Formate (71119-11-4 Free base) |
| MW: | 409.48 D |
ab 194,00 €
CHK1-IN-4 hydrochloride
Artikelnummer: TGM-T10792L-10mg
Description: CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1). CHK1-IN-4 hydrochloride potently inhibits chk1 phosphorylation in the tumor cells. CHK1-IN-4 hydrochloride has anti-tumor activity. Target: Chk. Smiles: Cl.COc1cc(Br)cc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1. References: Xiong...
| Schlagworte: | CHK1-IN-4 hydrochloride(2120398-41-4 Free base) |
| MW: | 480.75 D |
ab 195,00 €
CHPG hydrochloride
Artikelnummer: TGM-T10809L-5mg
Description: CHPG hydrochloride is a selective agonist of mGluR5. Target: NF-kappaB, GluR, ERK. Smiles: O=C(C(C1=CC(O)=CC=C1Cl)N)O.Cl. References: Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-kappaB pathway in BV2 microglial cells....
| Schlagworte: | CHPG hydrochloride(170846-74-9 Free base) |
| MW: | 238.07 D |
ab 52,00 €
Ciraparantag acetate
Artikelnummer: TGM-T10820L1-25mg
Description: Ciraparantag acetate, an anticoagulant reversal agent, is a small molecule specifically designed to bind noncovalently by charge-charge interaction to unfractionated heparin and low-molecular-weight heparin. It shows binding characteristics that are similar to those of direct oral anticoagulants...
| Schlagworte: | Ciraparantag acetate(1438492-26-2 Free base) |
| CAS | 1644388-83-9 |
| MW: | 572.75 D |
ab 40,00 €
Cletoquine hydrochloride
Artikelnummer: TGM-T10835L1-10mg
Description: Cletoquine hydrochloride is a major active metabolite of Hydroxychloroquine. Cletoquine hydrochloride is a Chloroquine derivative and exhibits the ability to against the chikungunya virus (CHIKV). Cletoquine hydrochloride exhibits antimalarial effects. Target: Parasite, Influenza Virus. Smiles:...
| Schlagworte: | Cletoquine hydrochloride( 4298-15-1 Free base) |
| CAS | 159358-29-9 |
| MW: | 344.28 D |
ab 117,00 €