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Orbifloxacin
Artikelnummer: Cay17353-50
Orbifloxacin is a fluoroquinolone antibiotic used in animals, including dogs, cattle, and swine, to combat gastrointestinal and respiratory infections. It is effective against most Gram-negative bacteria, including Enterobacteriaceae and Pseudomonas, with lower activity against Gram-positive aerobes.Formal Name:...
| Schlagworte: | CP 104,354, 1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5,6,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
| Anwendung: | Fluoroquinolone antibiotic, DNA gyrase inhibitor, topoisomerase IV inhibitor |
| CAS | 113617-63-3 |
| MW: | 395.4 D |
ab 61,00 €
Besifloxacin (hydrochloride)
Artikelnummer: Cay23692-5
Besifloxacin is an ophthalmologic fluoroquinolone antibiotic that is active against Gram-negative and Gram-positive aerobic and anaerobic bacterial strains (MICs = 0.006-1.56 µg/ml). It inhibits LPS-stimulated production of the inflammatory cytokines IL-1beta, IL-8, IL-6, and IL-1alpha in human THP-1 monocytes....
| Schlagworte: | BOL-303224-A,... |
| Anwendung: | Antibiotic, antibacterial, nucleic acid biosynthesis inhibitor |
| CAS | 405165-61-9 |
| MW: | 430.3 D |
ab 61,00 €
Elvitegravir
Artikelnummer: Cay17798-5
Elvitegravir is a quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM). It has antiviral activity against laboratory strains and clinical isolates of HIV-1 in MAGI cells (EC50s = 0.1-1.26 nM) and HIV-2 in peripheral blood mononuclear cells (PBMCs, EC50s = 0.3-0.9). Formulations containing elvitegravir...
| Schlagworte: | GS-9137, JTK-303,... |
| Anwendung: | HIV-1 integrase inhibitor |
| CAS | 697761-98-1 |
| MW: | 447.9 D |
ab 99,00 €
Nalidixic Acid
Artikelnummer: Cay19807-10
Nalidixic acid is a quinolone antibiotic. It is active against E. coli, Pasturella, K. pneumoniae, A. aerogenes, Proteus, Salmonella, and Shigella with minimum bacteriostatic concentrations (MBCs) ranging from 0.5 to 25 µg/ml. Nalidixic acid increases survival in mouse models of systemic K. pneumoniae, A. aerogenes,...
| Schlagworte: | NSC 82174, WIN 18,320, 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid |
| Anwendung: | Antibiotic, DNA gyrase / topoisomerase IV inhibitor |
| CAS | 389-08-2 |
| MW: | 232.2 D |
ab 44,00 €
Enrofloxacin
Artikelnummer: Cay20301-1
Enrofloxacin is a fluoroquinolone antibiotic. It is active against panels of Campylobacter, E. coli, and Salmonella isolates (mean MIC50s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates of L. intracellularis (MICs = 0.125-0.5 µg/ml). Enrofloxacin inhibits bacterial DNA gyrase....
| Schlagworte: | BAY-Vp 2674, ENR, PD 160788, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
| Anwendung: | Antibacterial antibiotic, DNA gyrase / topoisomerase IV inhibitor |
| CAS | 93106-60-6 |
| MW: | 359.4 D |
ab 44,00 €
Gemifloxacin (mesylate)
Artikelnummer: Cay21047-5
Gemifloxacin is a fluoroquinolone antibiotic that is effective against C. pneumoniae and M. tuberculosis (MIC50s = 0.25 and 8 µg/ml, respectively). Quinolones, including gemifloxacin, inhibit bacterial DNA gyrase and other topoisomerases. Formulations containing gemifloxacin are useful against respiratory tract...
| Schlagworte: | LB 20304a, SB 265805S,... |
| Anwendung: | Antibiotic, antibacterial, nucleic acid biosynthesis inhibitor, topoisomerase inhibitor |
| CAS | 210353-53-0 |
| MW: | 485.5 D |
ab 52,00 €
Flumequine
Artikelnummer: Cay21645-1
Flumequine is a fluoroquinolone antibiotic. It is active against S. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, and K. pneumoniae (MICs = 1-100 µg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 µg/ml). It inhibits DNA gyrase, disrupting...
| Schlagworte: | (±)-Flumequine, 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid |
| Anwendung: | DNA gyrase inhibitor, Antibacterial nucleic acid biosynthesis inhibitor |
| CAS | 42835-25-6 |
| MW: | 261.3 D |
ab 44,00 €
Marbofloxacin
Artikelnummer: Cay24174-1
Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 µg/ml). It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 µg/ml against various Gram-negative and Gram-positive...
| Schlagworte: | 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazine-6-carboxylic acid |
| Anwendung: | Antibacterial antibiotic |
| CAS | 115550-35-1 |
| MW: | 362.4 D |
ab 166,00 €
Trovafloxacin (mesylate)
Artikelnummer: Cay9000303-5
Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml).Formal Name:...
| Schlagworte: | CP 99,219,... |
| Anwendung: | Antibiotic |
| CAS | 147059-75-4 |
| MW: | 512.5 D |
ab 117,00 €
Ciprofloxacin (hydrochloride hydrate)
Artikelnummer: Cay14286-5
Ciprofloxacin is a fluoroquinolone antibiotic. It is active against a variety of Gram-positive and Gram-negative bacteria in vitro, including S. aureus, L. monocytogenes, P. aeruginosa, Legionella, N. gonorrhoeae, and H. pylori (MIC50s = 0.004-1 µg/ml). It is also active against clinical isolates of Bacteroides,...
| Schlagworte: | BAY-o 9867, NSC 620634, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid,... |
| Anwendung: | Antibiotic |
| CAS | 86393-32-0 |
| MW: | 367.8 D |
ab 44,00 €
Levofloxacin (hydrate)
Artikelnummer: Cay20382-1
Levofloxacin is a fluoroquinolone antibiotic and the active stereoisomer of ofloxacin (Cay-22891). It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 µg/ml, respectively). Levofloxacin inhibits S. aureus DNA gyrase and...
| Schlagworte: | MP-376,... |
| Anwendung: | Antibacterial, nucleic acid biosynthesis inhibitor |
| CAS | 138199-71-0 |
| MW: | 361.4 D |
ab 40,00 €
Ofloxacin
Artikelnummer: Cay22891-1
Ofloxacin is a broad-spectrum fluoroquinolone antibiotic that prevents supercoiling of bacterial chromosomes by DNA gyrase. It is active against Gram-positive and Gram-negative bacteria with MIC90s ranging from 0.39 to 3.13 µg/ml for clinical isolates of S. aureus, S. epidermidis, S. pyogenes, and S. faecalis and...
| Schlagworte: | DL-8280, WP0405,... |
| Anwendung: | Antibacterial antibiotic, DNA gyrase / topoisomerase IV inhibitor |
| CAS | 82419-36-1 |
| MW: | 361.4 D |
ab 44,00 €
Fleroxacin
Artikelnummer: Cay24173-1
Fleroxacin is a broad-spectrum fluoroquinolone antibiotic. It is active against a variety of Gram-positive and Gram-negative bacteria with MIC90 values ranging from 0.05 to 3.13 µg/ml for clinical isolates of Staphylococcus, P. aeruginosa, H. influenzae, N. gonorrhoeae, B. catarrhalis, C. jejuni, and various species...
| Schlagworte: | AM833, Ro 23-6240, 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid |
| Anwendung: | Antibacterial, broad-spectrum fluoroquinolone antibiotic, nucleic acid biosynthesis inhibitor |
| CAS | 79660-72-3 |
| MW: | 369.3 D |
ab 78,00 €
Temafloxacin
Artikelnummer: Cay17352-1
Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor. It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.Formal Name:...
| Schlagworte: | A-62254, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid |
| Anwendung: | Antibiotic, DNA topoisomerase inhibitor |
| CAS | 108319-06-8 |
| MW: | 417.4 D |
ab 61,00 €
Sparfloxacin
Artikelnummer: Cay20379-1
Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription. It is active against S. aureus with an MIC value of 0.031 µg/ml.Formal Name:...
| Schlagworte: | AT-4140, CI-978, CP 103,826, PD 131501, PD 1315-1,... |
| Anwendung: | Antibacterial, topoisomerase / gyrase inhibitor |
| CAS | 110871-86-8 |
| MW: | 392.4 D |
ab 44,00 €
Moxifloxacin-d4 (hydrochloride)
Artikelnummer: Cay22564-500
Moxifloxacin-d4 is intended for use as an internal standard for the quantification of moxifloxacin (Cay-14830) by GC- or LC-MS. Moxifloxacin is a fluoroquinolone antibiotic that is active through multiple routes of administration. Formulations containing moxifloxacin have been used to treat bacterial infections...
| Schlagworte: | BAY 12-8039-d4,... |
| Anwendung: | GC-MS, LC-MS, internal standard, Antibiotic, DNA gyrase / topoisomerase IV inhibitor |
| MW: | 441.9 D |
ab 259,00 €
Sarafloxacin (hydrochloride)
Artikelnummer: Cay20299-100
Sarafloxacin is a fluoroquinolone antibiotic. It is active against various clinical isolates of bacteria, including Bacteroides, Fusobacterium, Eubacterium, Actinomyces, and Peptococcus (MICs = 0.5-2 µg/ml). Sarafloxacin inhibits P. aeruginosa DNA gyrase. It decreases air sac lesion severity in a chick model of E....
| Schlagworte: | A-56620, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, monohydrochloride |
| Anwendung: | Veterinary fluoroquinolone antimicrobial agent, DNA gyrase/topoisomerase IV inhibitor |
| CAS | 91296-87-6 |
| MW: | 421.8 D |
ab 44,00 €
Danofloxacin (mesylate)
Artikelnummer: Cay22408-50
Danofloxacin is a fluoroquinolone antibiotic. In vitro, danofloxacin has activity against 68 field isolates of Mycoplasma species isolated from cattle, swine, and poultry with MICs ranging from 8 to 500 nM. It is protective in vivo against P. multocida, E. coli, and S. choleraesuis in mice with protective doses of...
| Schlagworte: | CP 76,136-27,... |
| Anwendung: | Antibacterial antibiotic, type II topoisomerase (DNA gyrase) inhibitor |
| CAS | 119478-55-6 |
| MW: | 453.5 D |
ab 61,00 €
Clinafloxacin (hydrochloride)
Artikelnummer: Cay16923-100
Clinafloxacin is a fluoroquinolone antibiotic that displays broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).Formal Name:...
| Schlagworte: | AM1091, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
| Anwendung: | Antibacterial antibiotic, DNA gyrase inhibitor, topoisomerase IV inhibitor |
| CAS | 105956-99-8 |
| MW: | 402.3 D |
ab 128,00 €
Tosufloxacin (tosylate)
Artikelnummer: Cay21427-100
Tosufloxacin is a fluoroquinolone antibiotic. It has activity against diverse aerobic and anaerobic bacteria in vitro. Tosufloxacin is also effective against bacterial persisters, showing significant activity against S. aureus and uropathogenic E. coli persisters. As with many other quinolones, tosufloxacin use can...
| Schlagworte: | 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid... |
| Anwendung: | Antibacterial antibiotic |
| CAS | 115964-29-9 |
| MW: | 576.5 D |
ab 78,00 €
Delafloxacin
Artikelnummer: Cay20314-5
Delafloxacin is a fluoroquinolone antibiotic that demonstrates extremely high potency against a wide range of bacteria in vitro, including levofloxacin-resistant strains of S. pneumoniae and methicillin-resistant S. aureus. It targets both DNA gyrase and topoisomerase IV. Delafloxacin has an anionic structure, which...
| Schlagworte: | ABT-492, RX-3341,... |
| Anwendung: | Antibacterial, topoisomerase IV inhibitor |
| CAS | 189279-58-1 |
| MW: | 440.8 D |
ab 67,00 €
Enoxacin
Artikelnummer: Cay16956-500
Enoxacin is a fluoroquinolone antibiotic. It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria, including S. aureus, E. coli, K. pneumoniae, P. aeruginosa, and S. marcescens (MIC50s = 1, 0.12, 0.25, 0.5, and 1 mg/L, respectively). Enoxacin inhibits S. aureus DNA gyrase...
| Schlagworte: | NSC 629661, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid |
| Anwendung: | Antibiotic, bacterial DNA gyrase / topoisomerase IV inhibitor |
| CAS | 74011-58-8 |
| MW: | 320.3 D |
ab 61,00 €
Moxifloxacin (hydrochloride)
Artikelnummer: Cay14830-50
Moxifloxacin is a fluoroquinolone antibiotic. It is active against 390 clinical isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria (MIC90s = =0.25 µg/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 µg/ml, respectively). Moxifloxacin...
| Schlagworte: | BAY 12-8039,... |
| Anwendung: | Antibiotic, DNA gyrase / topoisomerase IV inhibitor |
| CAS | 186826-86-8 |
| MW: | 437.9 D |
ab 128,00 €
Finafloxacin (hydrochloride)
Artikelnummer: Cay22410-500
Finafloxacin is a fluoroquinolone antibiotic. It is active against S. pneumoniae and P. aeruginosa, as well as methicillin-resistant S. aureus (MRSA) that is sensitive or resistant to fluoroquinolones (MIC90s = 2, 2, 0.125, and 4 mg/L, respectively). Finafloxacin (23.1 mg/kg) improves survival in F. tularensis- or...
| Schlagworte: | 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarb... |
| Anwendung: | Antibacterial nucleic acid biosynthesis inhibitor |
| CAS | 209342-41-6 |
| MW: | 434.9 D |
ab 250,00 €
Nadifloxacin
Artikelnummer: Cay20252-50
Nadifloxacin is a fluoroquinolone antibiotic. It is active against clinical isolates of S. aureus, coagulase-negative staphylococci, P. acnes, and P. granulosum (MIC50s = 0.03, 0.06, 0.25, and 0.125 mg/L, respectively). Nadifloxacin inhibits the activities of DNA gyrase and topoisomerase IV (IC50s = 8.83 and 3.22...
| Schlagworte: | OPC 7251, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid |
| Anwendung: | Fluoroquinolone antibiotic |
| CAS | 124858-35-1 |
| MW: | 360.4 D |
ab 44,00 €