Naveni PD1 PD-L1 BOND RX HRP

Naveni PD1/PD-L1 BOND RX HRP is a fully automated in situ kit for precise visualization of the interaction of PD1/PD-L1 within the tissue microenvironment. Naveni PD1/PD-L1 BOND RX HRP is seamlessly integrated for chromogenic readout on the Leica BOND RX platform. Naveni PD1/PD-L1 BOND RX HRP is based on the cutting-edge Naveni(R) in situ proximity ligation technology. Automation of the detection of PD1/PD-L1 interaction - high efficiency and reproducibility. The kit has the capacity for 30 slides in 1 run and is fully optimized with primary antibodies and detection kit included. PD-1 Protein function: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. [The UniProt Consortium] PD-L1 Protein function: Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). [The UniProt Consortium]